Children should NOT receive analgesia or antipyretics prior to vaccination.
Use of antipyretics e.g. paracetamol and ibuprofen, before or shortly after vaccination is common. However, a recent study has shown that antipyretics can reduce vaccine efficacy and should not be given routinely. They may be considered for treatment of fever >39.5oC or if a child had a large local reaction after vaccination.
Reference
- Prymula R, Siegrist CA, Chlibek R, Zemlickova H, Vackova M, Smetana J, Lommel P, Kaliskova E, Borys D, Schuerman L. Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. Lancet. 2009 Oct 17;374(9698):1339-50
Children can be given sucrose or glucose solutions prior to vaccination.
New research has shown an analgesic effect with use of sweet solutions (at least 30% glucose or 24% sucrose) immediately prior to vaccination in infants between 1 and 12 months of age.
Reference
- Harrison D, Stevens B, Bueno M, Yamada J, Adams-Webber T, Beyene J, Ohlsson A. Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: a systematic review.Arch Dis Child. 2010 Jun;95(6):406-13. Epub 2010 May 12. Review.
Egg allergy is NOT a contraindication to MMR vaccination.
Egg allergy (even anaphylaxis) is not a contraindication to MMR vaccination. Studies with a total of 1,000 patients with egg allergy found no evidence of anaphylaxis to MMR post vaccination.
References
- Fasano MB, Wood RA, Cooke SJ, Sampsom Ha Egg hypersensitivity and adverse reactions to measles, mumps, and rubella vaccine. J Pediatr 1992 June; 120 (6); 878-81
- Freigang B, Jadavji TP, Freigang DWLack of adverse reactions to measles, mumps, and rubella vaccine in egg-allergic children. Ann Allergy. 1994 Dec;73(6):486-8.
- Aickin R
,
Hill D
,
Kemp A
. Measles immunisation in children with allergy to egg. BMJ. 1994 Jul 23;309(6949):223-5.
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